{"product_id":"phospho-blnk-y96-polyclonal-antibody-bt-phs00687","title":"Phospho-BLNK (Y96) Polyclonal Antibody - BT-PHS00687","description":"\u003cp\u003ePhospho-BLNK (Y96) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-PHS00687-20, BT-PHS00687-50, BT-PHS00687-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: BLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. B-cell linker bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology; Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: BLNK\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, mouse, monkey\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Phospho-BLNK (Y96) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 50466\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q8WV28; Mouse: Q9QUN3\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: BLNK; BASH; SLP65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 29760; Mouse: 17060\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240015093939,"sku":"BT-PHS00687-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240015126707,"sku":"BT-PHS00687-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240015159475,"sku":"BT-PHS00687-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d8046714-129c-4f98-9cda-69d997ca74ad.png?v=1769402156","url":"https:\/\/afsbio.com\/products\/phospho-blnk-y96-polyclonal-antibody-bt-phs00687","provider":"AFSBio Inc.","version":"1.0","type":"link"}