{"product_id":"phospho-brca1-s1457-polyclonal-antibody-bt-phs00462","title":"Phospho-BRCA1 (S1457) Polyclonal Antibody - BT-PHS00462","description":"\u003cp\u003ePhospho-BRCA1 (S1457) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-PHS00462-20, BT-PHS00462-50, BT-PHS00462-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: BRCA1 (BRCA1, DNA repair associated) encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in BRCA1 are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for BRCA1, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling; Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: BRCA1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Phospho-BRCA1 (S1457) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 207721\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P38398; Mouse: P48754\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 672\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240011587763,"sku":"BT-PHS00462-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240011620531,"sku":"BT-PHS00462-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240011653299,"sku":"BT-PHS00462-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_747bc995-5f6a-436c-85b6-8e33cbd9c4a9.png?v=1769402100","url":"https:\/\/afsbio.com\/products\/phospho-brca1-s1457-polyclonal-antibody-bt-phs00462","provider":"AFSBio Inc.","version":"1.0","type":"link"}