{"product_id":"phospho-caldesmon-s759-polyclonal-antibody-bt-phs01084","title":"Phospho-Caldesmon (S759) Polyclonal Antibody - BT-PHS01084","description":"\u003cp\u003ePhospho-Caldesmon (S759) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-PHS01084-20, BT-PHS01084-50, BT-PHS01084-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CALD1 (caldesmon 1) encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CALD1\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, mouse, rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Phospho-Caldesmon (S759) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): high molecular weight (predominantly in smooth muscles) (120-150 KD) and a low molecular weight (60\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q05682; Rat: Q62736\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CALD1; CAD; CDM; Caldesmon; CDM\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 800; Rat: 25687\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240022958259,"sku":"BT-PHS01084-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240022991027,"sku":"BT-PHS01084-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240023023795,"sku":"BT-PHS01084-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_6a52bae3-ff4a-40dd-bdbf-192a2f83a074.png?v=1769402279","url":"https:\/\/afsbio.com\/products\/phospho-caldesmon-s759-polyclonal-antibody-bt-phs01084","provider":"AFSBio Inc.","version":"1.0","type":"link"}