{"product_id":"phospho-catalase-y386-polyclonal-antibody-bt-phs00728","title":"Phospho-Catalase (Y386) Polyclonal Antibody - BT-PHS00728","description":"\u003cp\u003ePhospho-Catalase (Y386) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-PHS00728-20, BT-PHS00728-50, BT-PHS00728-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CAT (catalase) encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in CAT have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by CAT.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Tags and Cell Markers; Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CAT\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, mouse, rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Phospho-Catalase (Y386) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 59756\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P04040; Mouse: P24270; Rat: P04762\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CAT; Catalase\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 847; Mouse: 12359; Rat: 24248\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240016273587,"sku":"BT-PHS00728-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240016306355,"sku":"BT-PHS00728-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240016339123,"sku":"BT-PHS00728-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_41541319-e39d-407a-a67f-b3785e9613c9.png?v=1769402179","url":"https:\/\/afsbio.com\/products\/phospho-catalase-y386-polyclonal-antibody-bt-phs00728","provider":"AFSBio Inc.","version":"1.0","type":"link"}