{"product_id":"phospho-catenin-beta-ser37-polyclonal-antibody-e-ab-20828","title":"Phospho-Catenin beta (Ser37) Polyclonal Antibody - E-AB-20828","description":"\u003cp\u003ePhospho-Catenin beta (Ser37) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-20828-60, E-AB-20828-120, E-AB-20828-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Catenin-β (phospho Ser37)\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Beta catenin; Beta-catenin; Cadherin associated protein; Catenin (cadherin associated protein); beta 1; 88kDa; Catenin beta 1; Catenin beta-1; CATNB; CHBCAT; CTNB1; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923; OTTHUMP00000162082; OTTHUMP00000165222; OTTHUMP00000165223; OTTHUMP00000209288; OTTHUMP00000209289\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P35222\u003c\/p\u003e\n\n\u003cp\u003eBackground: Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF\/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin\/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human Catenin-β around the phosphorylation site of  Ser37\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 85kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 85kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43145998205107,"sku":"E-AB-20828-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43145998237875,"sku":"E-AB-20828-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43145998270643,"sku":"E-AB-20828-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_0c0665d1-280c-4be4-9ca6-29af8e6cd028.png?v=1710289540","url":"https:\/\/afsbio.com\/products\/phospho-catenin-beta-ser37-polyclonal-antibody-e-ab-20828","provider":"AFSBio Inc.","version":"1.0","type":"link"}