{"product_id":"phospho-catenin-beta-t41-s45-polyclonal-antibody-bt-phs00048","title":"Phospho-Catenin-Beta (T41\/S45) Polyclonal Antibody - BT-PHS00048","description":"\u003cp\u003ePhospho-Catenin-Beta (T41\/S45) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-PHS00048-20, BT-PHS00048-50, BT-PHS00048-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Catenin beta 1 encoded by CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Catenin beta 1 also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, catenin beta 1 binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for CTNNB1.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CTNNB1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, mouse, rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Phospho-Catenin-beta (T41\/S45) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 85497\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P35222; Mouse: Q02248; Rat: Q9WU82\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CTNNB1; CTNNB; OK\/SW-cl.35; Catenin beta-1; Beta-catenin\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1499; Mouse: 12387; Rat: 84353\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240008212659,"sku":"BT-PHS00048-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240008245427,"sku":"BT-PHS00048-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240008278195,"sku":"BT-PHS00048-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_37b829d3-0234-4c84-970a-f81382d92824.png?v=1769402053","url":"https:\/\/afsbio.com\/products\/phospho-catenin-beta-t41-s45-polyclonal-antibody-bt-phs00048","provider":"AFSBio Inc.","version":"1.0","type":"link"}