{"product_id":"phospho-cd22-y807-polyclonal-antibody-bt-phs00448","title":"Phospho-CD22 (Y807) Polyclonal Antibody - BT-PHS00448","description":"\u003cp\u003ePhospho-CD22 (Y807) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-PHS00448-20, BT-PHS00448-50, BT-PHS00448-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD22, also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule), is a 130-140 kDa, B-cell restricted, type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling, preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CD22\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Phospho-CD22 (Y807) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 95348\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P20273; Mouse: P35329\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CD22; SIGLEC2; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD antigen CD22\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 933\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240011194547,"sku":"BT-PHS00448-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240011227315,"sku":"BT-PHS00448-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240011260083,"sku":"BT-PHS00448-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_6706afc0-bc3a-4f53-a640-10e9215f207e.png?v=1769402095","url":"https:\/\/afsbio.com\/products\/phospho-cd22-y807-polyclonal-antibody-bt-phs00448","provider":"AFSBio Inc.","version":"1.0","type":"link"}