{"product_id":"phospho-cyclin-d1-thr286-cyclin-d2-thr280-recombinant-rabbit-monoclonal-antibody-bs43386","title":"Phospho-Cyclin D1 (Thr286)\/Cyclin D2 (Thr280) Recombinant Rabbit Monoclonal Antibody - BS43386","description":"\u003cp\u003ePhospho-Cyclin D1 (Thr286)\/Cyclin D2 (Thr280) Recombinant Rabbit mAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS43386-50, BS43386-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regμlators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regμlatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1\/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regμlated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: BCL1, PRAD1, U21B31, D11S287E\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylated\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic phosphopeptide corresponding to residues surrounding Thr286 of human Cyclin D1\u003c\/p\u003e \n\n\u003cp\u003eDilution: WB: 1:1000\u003c\/p\u003e\n\n\u003cp\u003ePurification: Affinity Purification\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 36 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P24385\u003c\/p\u003e\n\n\u003cp\u003eProduct: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45937146986675,"sku":"BS43386-50","price":424.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45937147019443,"sku":"BS43386-100","price":642.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image.jpg?v=1788296056","url":"https:\/\/afsbio.com\/products\/phospho-cyclin-d1-thr286-cyclin-d2-thr280-recombinant-rabbit-monoclonal-antibody-bs43386","provider":"AFSBio Inc.","version":"1.0","type":"link"}