{"product_id":"phospho-erbb-2-tyr1221-tyr1222-polyclonal-antibody-bz16411","title":"Phospho-ErbB 2 (Tyr1221\/Tyr1222) Polyclonal Antibody-BZ16411","description":"\u003cp\u003ePhospho-ErbB 2 (Tyr1221\/Tyr1222) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BZ16411-50, BZ16411-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P04626\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-P, IP, , ELISA\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1\/500-1\/1000  IHC: 1\/50-1\/100  IP: 1\/20  ELISA: 1\/10000\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: Calculated MW: 138 kDa; Observed MW: 180 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of Phospho-ErbB 2 in various lysates using Phospho-ErbB 2 antibody., Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma, using HER2 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right., Western blot analysis of Phospho-ErbB 2 in SKOV-3 lysates treated with EGF, using HER2 antibody. The Lane on the right is blocked with the Phospho- peptide.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human HER2 around the phosphorylation site of Tyr1221\/Tyr1222. AA range:1191-1240\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42999933141171,"sku":"BZ16411-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42999933173939,"sku":"BZ16411-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_d503ede7-cbbd-454c-bddd-6cf90bcff199.jpg?v=1706358321","url":"https:\/\/afsbio.com\/products\/phospho-erbb-2-tyr1221-tyr1222-polyclonal-antibody-bz16411","provider":"AFSBio Inc.","version":"1.0","type":"link"}