{"product_id":"phospho-hdac5-ser498-polyclonal-antibody-e-ab-20888","title":"Phospho-HDAC5 (Ser498) Polyclonal Antibody - E-AB-20888","description":"\u003cp\u003ePhospho-HDAC5 (Ser498) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-20888-60, E-AB-20888-120, E-AB-20888-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: HDAC5 (phospho Ser498)\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Antigen NY CO 9; Antigen NY-CO-9; HD5; HDAC 5; HDAC5; HDAC5; Histone deacetylase 5; NY CO 9\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9UQL6\u003c\/p\u003e\n\n\u003cp\u003eBackground: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human HDAC5 around the phosphorylation site of  Ser498\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 122kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 122kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146000269491,"sku":"E-AB-20888-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146000302259,"sku":"E-AB-20888-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146000335027,"sku":"E-AB-20888-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_1bee4583-e792-463a-8cf3-2c7362f208bb.png?v=1710289558","url":"https:\/\/afsbio.com\/products\/phospho-hdac5-ser498-polyclonal-antibody-e-ab-20888","provider":"AFSBio Inc.","version":"1.0","type":"link"}