{"product_id":"phospho-igf-ireceptorβ-tyr1135-1136-insμlinreceptorβ-tyr1150-1151-polyclonal-antibody-bs74229","title":"Phospho-IGF-IReceptorβ (Tyr1135\/1136)\/InsμlinReceptorβ (Tyr1150\/1151) Polyclonal Antibody - BS74229","description":"\u003cp\u003ePhospho-IGF-IReceptorβ (Tyr1135\/1136)\/InsμlinReceptorβ (Tyr1150\/1151) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS74229-50, BS74229-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insμlin or other ligands to this receptor activates the insμlin signaling pathway, which regμlates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insμlin resistance syndromes including type A insμlin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing resμlts in mμltiple transcript variants.This receptor binds insμlin-like growth factor with a high affinity. It has tyrosine kinase activity. The insμlin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: HHF5, CD220, IGFR, CD221, IGFIR, JTK13\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylated\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: A synthetic phosphorylated peptide around IReceptorβ(Tyr1135\/1136)\/InsμlinReceptorβ(Tyr1150\/1151) of human(Tyr1150\/1151) of human IGF.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB, 1:500 - 1:2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Phosphorylated\u003c\/p\u003e \n\n\u003cp\u003eMolecular Weight: 102KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P06213\/P08069\u003c\/p\u003e\n\n\u003cp\u003eProduct: 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45939975291059,"sku":"BS74229-50","price":424.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45939975323827,"sku":"BS74229-100","price":642.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_41a3d5a7-cf33-4737-a858-16025b1d8d02.jpg?v=1788296283","url":"https:\/\/afsbio.com\/products\/phospho-igf-ireceptor%ce%b2-tyr1135-1136-ins%ce%bclinreceptor%ce%b2-tyr1150-1151-polyclonal-antibody-bs74229","provider":"AFSBio Inc.","version":"1.0","type":"link"}