{"product_id":"phospho-jnk1-t183-y185-jnk2-t183-y185-jnk3-t221-y223-rabbit-pab-ap1163","title":"Phospho-JNK1-T183\/Y185 + JNK2-T183\/Y185 + JNK3-T221\/Y223 Rabbit pAb - AP1163","description":"\u003cp\u003ePhospho-JNK1-T183\/Y185 + JNK2-T183\/Y185 + JNK3-T221\/Y223 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: AP1163-20, AP1163-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]\u003c\/p\u003e\n\n\u003cp\u003eApplications: Phosphorylated Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 35kDa\/44kDa\/48kDa\/27kDa\/52kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 46kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5599\/5601\/5602\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P45983\/P45984\/P53779\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: MAPK8\/MAPK9\/MAPK10\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189377622195,"sku":"AP1163-20","price":179.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189377654963,"sku":"AP1163-100","price":515.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_4c0edc38-4054-4f9b-a870-c73092dd6be4.png?v=1766425774","url":"https:\/\/afsbio.com\/products\/phospho-jnk1-t183-y185-jnk2-t183-y185-jnk3-t221-y223-rabbit-pab-ap1163","provider":"AFSBio Inc.","version":"1.0","type":"link"}