{"product_id":"phospho-kcnq2-3-4-5-thr217-thr246-thr223-thr251-polyclonal-antibody-bz16487","title":"Phospho-KCNQ2\/3\/4\/5 (Thr217\/Thr246\/Thr223\/Thr251) Polyclonal Antibody-BZ16487","description":"\u003cp\u003ePhospho-KCNQ2\/3\/4\/5 (Thr217\/Thr246\/Thr223\/Thr251) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BZ16487-50, BZ16487-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O43526\/O43525\/P56696\/Q9NR82\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-P, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IHC: 1\/50-1\/100  ELISA: 1\/10000\u003c\/p\u003e\n\n\u003cp\u003eBackground: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: -\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: EnzymeLinked Immunosorbent Assay for Immunogen Phospho-peptide and NonPhospho-peptide , using Kv7. 3\/KCNQ3 (Phospho-Thr24antibody, Immunohistochemical analysis of paraffin-embedded Human tonsils using Phospho-KCNQ2\/3\/4\/5 antibody. Sample with blocking peptide on the right. High-pressure and temperature Sodium Citrate pH 6. 0 was used for antigen retrieval.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: KCNQ2; Potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2; KCNQ3; Potassium voltage-gated channel subfamily KQT me\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human Kv7.3\/KCNQ3 around the phosphorylation site of Thr246. AA range:191-240\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42970473332915,"sku":"BZ16487-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42970473365683,"sku":"BZ16487-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_d0182b51-9fc7-4b1e-adef-2071676822eb.jpg?v=1705525869","url":"https:\/\/afsbio.com\/products\/phospho-kcnq2-3-4-5-thr217-thr246-thr223-thr251-polyclonal-antibody-bz16487","provider":"AFSBio Inc.","version":"1.0","type":"link"}