{"product_id":"phospho-map3k5-t845-rabbit-pab-ap1215","title":"Phospho-MAP3K5-T845 Rabbit pAb - AP1215","description":"\u003cp\u003ePhospho-MAP3K5-T845 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: AP1215-20, AP1215-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Enables MAP kinase kinase kinase activity and protein kinase binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of JNK cascade; and positive regulation of cell death. Acts upstream of or within several processes, including cellular response to reactive nitrogen species; intracellular signal transduction; and positive regulation of MAPK cascade. Predicted to be located in cytoplasm. Predicted to be part of IRE1-TRAF2-ASK1 complex and protein kinase complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Human ortholog (s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).\u003c\/p\u003e\n\n\u003cp\u003eApplications: Phosphorylated Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 155kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 155kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 26408\u003c\/p\u003e\n\n\u003cp\u003eSWISS: O35099\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ASK; ASK1; Mekk5; MAPKKK5; 7420452D20Rik; Phospho-MAP3K5-T845\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: Map3k5\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189416943795,"sku":"AP1215-20","price":179.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189416976563,"sku":"AP1215-100","price":515.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_e725c9f2-c382-4228-a9ce-a9ef7c5f1cad.png?v=1766426712","url":"https:\/\/afsbio.com\/products\/phospho-map3k5-t845-rabbit-pab-ap1215","provider":"AFSBio Inc.","version":"1.0","type":"link"}