{"product_id":"phospho-mlkl-s358-6b4-mouse-monoclonal-antibody-em1320","title":"phospho-MLKL (S358) (6B4) Mouse Monoclonal Antibody - EM1320","description":"\u003cp\u003ephospho-MLKL (S358) (6B4) Mouse Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: EM1320-50, EM1320-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Mixed lineage kinase domain like protein, FLJ34389\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG1\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:100-200\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 54kDa\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane,  Cytoplasm,  Membrane\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46316459688115,"sku":"EM1320-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46316459720883,"sku":"EM1320-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/phospho-mlkl-s358-6b4-mouse-monoclonal-antibody-em1320","provider":"AFSBio Inc.","version":"1.0","type":"link"}