{"product_id":"phospho-mlkl-s358-mouse-monoclonal-antibody-6f8-bt-mca1026","title":"phospho-MLKL (S358) mouse Monoclonal Antibody (6F8) - BT-MCA1026","description":"\u003cp\u003ephospho-MLKL (S358) mouse Monoclonal Antibody (6F8)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-MCA1026-20, BT-MCA1026-50, BT-MCA1026-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain| however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction; Cancer; Microbiology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MLKL\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF, ICC, IHC-p\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MLKL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q8NB16; Mouse: Q9D2Y4\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: MLKL\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 197259\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240046059699,"sku":"BT-MCA1026-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240046092467,"sku":"BT-MCA1026-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240046125235,"sku":"BT-MCA1026-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_98be318f-0342-411a-870f-aa18867716a9.png?v=1769402635","url":"https:\/\/afsbio.com\/products\/phospho-mlkl-s358-mouse-monoclonal-antibody-6f8-bt-mca1026","provider":"AFSBio Inc.","version":"1.0","type":"link"}