{"product_id":"phospho-p53bp1-ser25-ser29-polyclonal-antibody-bs65621","title":"phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody - BS65621","description":"\u003cp\u003ephospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65621-50, BS65621-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: p53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-P\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: 53BP1 (phospho S25), p-53BP1 (phospho S25) , 53BP1 (Phospho-Ser25\/29), 53BP1 (Phospho-S25\/S29), phospho-p53BP1(Ser25\/Ser29), P-53BP1 (Ser25\/29), 53 BP1, FLJ41424, MGC138366, p202, p53 binding protein 1, p53 BP1, p53BP1, TP53 BP1, TP53BP1, Tumor protein 53 binding protein 1, Tumor protein p53 binding protein 1, Tumor suppressor p53 binding protein 1, TP53B_HUMAN, tumor protein 53-binding protein, 1.\u003c\/p\u003e \n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH conjugated Synthesised phosphopeptide derived from human p53BP1 around the phosphorylation site of Ser25\/29:ED(p-S)QPE(p-S)QV\u003c\/p\u003e \n\n\u003cp\u003eDilution: IHC-P=1:100-500\u003c\/p\u003e \n\n\u003cp\u003ePurification: affinity purified by Protein A\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody detects endogenous levels of phospho-p53BP1 protein only when phosphorylated at Ser25 + Ser29.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 213kD\u003c\/p\u003e\n\n\u003cp\u003ePathway: Cell Cycle G2 M DNA Damage Signaling Pathway,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q12888\u003c\/p\u003e\n\n\u003cp\u003eProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946360398003,"sku":"BS65621-50","price":349.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946360430771,"sku":"BS65621-100","price":642.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/phospho-p53bp1-ser25-ser29-polyclonal-antibody-bs65621","provider":"AFSBio Inc.","version":"1.0","type":"link"}