{"product_id":"phospho-progesterone-receptorser190-polyclonal-antibody-bs65628","title":"Phospho-Progesterone Receptor(Ser190) Polyclonal Antibody-BS65628","description":"\u003cp\u003ePhospho-Progesterone Receptor(Ser190) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65628-50, BS65628-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q63449\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Mouse, Rat, Cow,\u003c\/p\u003e \n\n\u003cp\u003eApplications: WB,\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB=1:500-2000\u003c\/p\u003e \n\n\u003cp\u003eBackground: Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Aand hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: affinity purified by Protein A\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody detects endogenous levels of Phospho-Progesterone Receptor protein only when phosphorylated at Ser190\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 110 kD\/ 120kD\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Sample:\u003cbr\u003e\n Lane 1: Uterus (Mouse) Lysate at 40 ug\u003cbr\u003e\n Lane 2: Testis (Mouse) Lysate at 40 ug\u003cbr\u003e\n Lane 3: Testis (Rat) Lysate at 40 ug\u003cbr\u003e\n Lane 4: MCF-7 (Human) Cell Lysate at 30 ug\u003cbr\u003e\n Lane 5: HepG2 (Human) Cell Lysate at 30 ug\u003cbr\u003e\n Lane 6: Hela (Human) Cell Lysate at 30 ug\u003cbr\u003e\n Primary: Anti-progesterone receptor at 1\/1000 dilution, Sample:\u003cbr\u003e\n Lane 1: MCF-7 (Human) Cell Lysate at 30 ug\u003cbr\u003e\n Lane 2: Uterus (Mouse) Lysate at 40 ug\u003cbr\u003e\n Primary: Anti-Phospho-Progesterone Receptor (Ser190) at 1\/1000 dilution\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: PGR(phospho S190); NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRA; PRB; Progesterone receptor; Progestin receptor form A; Progestin receptor form B; PRGR_RAT.\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH conjugated Synthesised phosphopeptide derived from rat Progesterone Receptor around the phosphorylation site of Ser190\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42975431852211,"sku":"BS65628-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42975431884979,"sku":"BS65628-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_becd0f10-5e7e-42b2-b805-24e8d803f6e0.jpg?v=1705665957","url":"https:\/\/afsbio.com\/products\/phospho-progesterone-receptorser190-polyclonal-antibody-bs65628","provider":"AFSBio Inc.","version":"1.0","type":"link"}