{"product_id":"phospho-rb-ser780-monoclonal-antibody-mb11518","title":"Phospho-Rb (Ser780) Monoclonal Antibody-MB11518","description":"\u003cp\u003ePhospho-Rb (Ser780) Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB11518-50, MB11518-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P06400\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB,IP\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1\/500-1\/1000  IP: 1\/20\u003c\/p\u003e  \n\n\u003cp\u003eBackground: Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression. Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4\/6 followed by cyclin E-CDK2 phosphorylation. Specificity of different CDK\/cyclin complexes has been observed in vitro and cyclin D1 is required for Ser780 phosphorylation in vivo.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of Phospho-Rb in K562, C6Lysates using Phospho-Rb antibody.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: Calculated MW: 106 kDa; Observed MW: 110 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser780 of human Rb\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42938002931891,"sku":"MB11518-50","price":415.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42938002964659,"sku":"MB11518-100","price":640.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_ea89ddd3-132f-4a28-9fa2-6845765f375f.jpg?v=1704458427","url":"https:\/\/afsbio.com\/products\/phospho-rb-ser780-monoclonal-antibody-mb11518","provider":"AFSBio Inc.","version":"1.0","type":"link"}