{"product_id":"pi51a-rabbit-polyclonal-antibody-es14115","title":"PI51A Rabbit Polyclonal Antibody - ES14115","description":"\u003cp\u003ePI51A Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES14115-50, ES14115-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human PI51A AA range: 270-320\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: PI51A\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of PI51A at Human\/Mouse\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.99% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas, Detected at lower levels in brain, lung and liver,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 60kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, Phospholipase D signaling pathway, Endocytosis, Focal adhesion, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, Yersinia infection, Choline metabolism in cancer\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate\u003cbr\u003e\nFunction: Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2\u003cbr\u003e\nSimilarity: Contains 1 PI5K domain\u003cbr\u003e\nSubcellular Location: Associated with the plasma membrane and with internal membranes. Associated with Golgi stacks (By similarity). Detected on RAC1-induced plasma membrane ruffles, and on membrane ruffles induced by platelet-derived growth factor\u003cbr\u003e\nSubunit: Interacts with ARF1, RAC1, PLD1, PLD2 and JUB\u003cbr\u003e\nTissue Specificity: Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cell membrane Cytoplasm Nucleus Nucleus speckle Cell projection, ruffle Cell projection, lamellipodium Colocalizes with RAC1 at actin-rich membrane ruffles (PubMed:20660631) Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs (PubMed:18288197)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: PIP5K1A\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: PI51A\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 18720\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P70182\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315123343539,"sku":"ES14115-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315123376307,"sku":"ES14115-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/pi51a-rabbit-polyclonal-antibody-es14115","provider":"AFSBio Inc.","version":"1.0","type":"link"}