{"product_id":"pim-1-phospho-tyr309-polyclonal-antibody-ra21208","title":"Pim-1 (phospho Tyr309) Polyclonal Antibody - RA21208","description":"\u003cp\u003ePim-1 (phospho Tyr309) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA21208-50, RA21208-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Pim-1 proto-oncogene, serine\/threonine kinase (PIM1) Homo sapiens The protein encoded by this gene belongs to the Ser\/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810) .[provided by RefSeq, Aug 2011],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: PIM1; Serine\/threonine-protein kinase pim-1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 5292\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 45\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P11309\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45120731087027,"sku":"RA21208-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45120731119795,"sku":"RA21208-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_b34de931-eae6-4645-9c50-d2dd0ca9d580.png?v=1773370073","url":"https:\/\/afsbio.com\/products\/pim-1-phospho-tyr309-polyclonal-antibody-ra21208","provider":"AFSBio Inc.","version":"1.0","type":"link"}