{"product_id":"pim1-polyclonal-antibody-e-ab-66245","title":"PIM1 Polyclonal Antibody - E-AB-66245","description":"\u003cp\u003ePIM1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-66245-60, E-AB-66245-120, E-AB-66245-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PIM1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: PIM; PIM1; PIM1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction, Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P11309\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the Ser\/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human PIM1 (NP_002639.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 35kDa\/45kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 35kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146411606195,"sku":"E-AB-66245-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146411638963,"sku":"E-AB-66245-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146411671731,"sku":"E-AB-66245-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_da630606-1da1-49ac-bfd9-b383617f78e1.png?v=1710295107","url":"https:\/\/afsbio.com\/products\/pim1-polyclonal-antibody-e-ab-66245","provider":"AFSBio Inc.","version":"1.0","type":"link"}