{"product_id":"pin1-polyclonal-antibody-e-ab-60610","title":"PIN1 Polyclonal Antibody - E-AB-60610","description":"\u003cp\u003ePIN1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-60610-60, E-AB-60610-120, E-AB-60610-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PIN1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: PIN1; DOD; UBL5\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q13526\u003c\/p\u003e\n\n\u003cp\u003eBackground: Peptidyl-prolyl cis\/trans isomerases (PPIases) catalyze the cis\/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser\/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human PIN1 (NP_006212.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 18kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 18kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146091659443,"sku":"E-AB-60610-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146091692211,"sku":"E-AB-60610-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146091724979,"sku":"E-AB-60610-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_0fc25ecc-fa6b-4d08-92ad-bcc496c1e687.png?v=1710290849","url":"https:\/\/afsbio.com\/products\/pin1-polyclonal-antibody-e-ab-60610","provider":"AFSBio Inc.","version":"1.0","type":"link"}