{"product_id":"pinch-3c12-monoclonal-antibody-mb3154","title":"PINCH (3C12) Monoclonal Antibody-MB3154","description":"\u003cp\u003ePINCH (3C12) Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB3154-50, MB3154-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P48059\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC\/IF, FC, IP,\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1\/500-1\/1000  IF: 1\/50-1\/200  IP: 1\/20  FC: 1\/50-1\/100\u003c\/p\u003e  \n\n\u003cp\u003eBackground: The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG1\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: Calculated MW: 37 kDa; Observed MW: 37 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Immunoprecipitation analysis of PINCH in Hela lysates using PINCH antibody., Western blot analysis of PINCH in C6, Jurkat, K562, 3T3 and Hela lysates using PINCH antibody, Immunofluorescence analysis of PINCH in HepG2 cells using PINCH antibody and DAPI., Flow cytometry analysis of Hela stained with PINCH antibody and negative control.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: LIMS1; PINCH; PINCH1; LIM and senescent cell antigen-like-containing domain protein 1; Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human PINCH expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":43055898886323,"sku":"MB3154-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":43055898919091,"sku":"MB3154-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_e72d04fb-f457-463e-a520-57ccd622564c.jpg?v=1708086258","url":"https:\/\/afsbio.com\/products\/pinch-3c12-monoclonal-antibody-mb3154","provider":"AFSBio Inc.","version":"1.0","type":"link"}