{"product_id":"pink1-polyclonal-antibody-bs91075","title":"PINK1 Polyclonal Antibody-BS91075","description":"\u003cp\u003ePINK1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91075-50, BS91075-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9BXM7\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1000\u003cbr\u003e\nIHC:1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: A member of the serine \/ threonine protein kinase family, PTEN induced putative kinase 1 (PINK1) is a tumor suppressor. PINK1 is primarily located in mitochondria, and is ubiquitously expressed in testis, skeletal muscle, and heart tissue. at lower levels in pancreas, ovary, brain, placenta, kidney, liver, prostate and small intestine. During cellular stress PINK1 protects against mitochondrial dysfunction by inducing phosphorylation mitochondrial proteins. PINK1 mutations may give rise to different autophosphorylation activity. Mutations in the PINK1 gene (PARK6) are associated with early onset Parkinson's disease, a recessive neurodegenerative disorder characterized by resting tremor, muscular rigidity, bradykinesia and postural instability. Parkinson's disease generally involves the presence of intraneuronal accumulations of aggregated proteins (Lewy bodies) in brain neurons.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Protein affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PINK1 polyclonal antibody detects endogenous levels of PINK1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 60kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of extracts of various cell lines, using PINK1 antibody at 1:1000 dilution., Immunohistochemistry of paraffin-embedded human colon cancer using PINK1 antibody at dilution of 1:100 (40x lens).\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: PINK1, BRPK, FLJ27236, mitochondrial, PARK 6, PARK6, Phosphatase and Tensin Homolog, PINK 1, PINK1, PINK1, Protein kinase BRPK, PTEN induced putative kinase 1, PTEN induced putative kinase protein 1, PTEN-induced putative kinase protein 1, Serine\/threonine kinase PINK1 mitochondrial, Serine\/threonine protein kinase PINK1 mitochondrial, Serine\/threonine-protein kinase PINK1,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42975432212659,"sku":"BS91075-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42975432245427,"sku":"BS91075-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_045c12f4-b8cb-4380-a9a6-dc22c7ceab3b.jpg?v=1705665965","url":"https:\/\/afsbio.com\/products\/pink1-polyclonal-antibody-bs91075","provider":"AFSBio Inc.","version":"1.0","type":"link"}