{"product_id":"pinx1-rabbit-pab-es6688","title":"PinX1 rabbit pAb - ES6688","description":"\u003cp\u003ePinX1 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6688-50, ES6688-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: domain:The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity., function:Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor., similarity:Belongs to the PINX1 family., similarity:Contains 1 G-patch domain., subcellular location:In nucleoli and at telomere speckles., subunit:Binds to MCRS1, TERT and TERF1., tissue specificity:Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: PINX1; LPTL; LPTS; PIN2\/TERF1-interacting telomerase inhibitor 1; Liver-related putative tumor suppressor; Pin2-interacting protein X1; Protein 67-11-3; TRF1-interacting protein 1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human PINX1. AA range:121-170\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 54984\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q96BK5\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201925210291,"sku":"ES6688-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201925243059,"sku":"ES6688-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_2b71d776-b228-4fcb-bb31-4c58dc4ec54d.png?v=1767118106","url":"https:\/\/afsbio.com\/products\/pinx1-rabbit-pab-es6688","provider":"AFSBio Inc.","version":"1.0","type":"link"}