{"product_id":"pirh2-monoclonal-antibody-bt-mca4310","title":"Pirh2 Monoclonal Antibody - BT-MCA4310","description":"\u003cp\u003ePirh2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4310-50, BT-MCA4310-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Pirh 2 (P53 induced RING-H2 protein), also known as RCHY1, it forms dimers through its N- and C-terminus in cells. The Pirh2 has ubiquitin-protein ligase activity and it binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. The Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 expression decreases the level of p53, and a decrease of endogenous Pirh2 expression increases p53 levels. Pirh2 is therefore considered, together with MDM2, to act as a negative regulator of p53 function.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: Pirh2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, ICC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 1H10\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Pirh2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human Pirh2 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 30kDa; 60kDa (homodimer)\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q96PM5\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ARNIP, CHIMP, RNF199, RCHY1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 25898\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238623502515,"sku":"BT-MCA4310-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238623535283,"sku":"BT-MCA4310-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f41fcde0-769e-4984-8a09-5379407a585d.png?v=1769383167","url":"https:\/\/afsbio.com\/products\/pirh2-monoclonal-antibody-bt-mca4310","provider":"AFSBio Inc.","version":"1.0","type":"link"}