{"product_id":"pkaα-cat-phospho-ser338-polyclonal-antibody-ra28791","title":"PKAα cat (phospho Ser338) Polyclonal Antibody - RA28791","description":"PKAα cat (phospho Ser338) Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA28791-50, RA28791-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: protein kinase cAMP-activated catalytic subunit alpha (PRKACA) Homo sapiens This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Altern\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/5000. Not yet tested in other applications.\n\nAlternative Names: PRKACA; PKACA; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha\n\nApplications: IHC-p; IF (paraffin section) ; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse; Rat\n\nGeneID (Human): 5566\n\nSWISS: P17612\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45120354320563,"sku":"RA28791-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45120354353331,"sku":"RA28791-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_af126be2-ca8d-493a-8b98-287f2d87c7ee.png?v=1773357562","url":"https:\/\/afsbio.com\/products\/pka%ce%b1-cat-phospho-ser338-polyclonal-antibody-ra28791","provider":"AFSBio Inc.","version":"1.0","type":"link"}