{"product_id":"pka-c-phospho-thr197-rabbit-polyclonal-antibody-bt-ap11958","title":"PKA C (Phospho-Thr197) Rabbit Polyclonal Antibody - BT-AP11958","description":"\u003cp\u003ePKA C (Phospho-Thr197) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP11958-20, BT-AP11958-50, BT-AP11958-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes one of the catalytic subunits of protein kinase A| which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits| in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes| including differentiation| proliferation| and apoptosis. Constitutive activation of this gene caused either by somatic mutations| or genomic duplications of regions that include this gene| have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushingandapos;s syndrome. Altern\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; Cardiovascular; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PRKACA\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PKA C\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P17612; Mouse: P05132; Rat: P27791\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PKA C;Thr197; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; EC 2.7.11.11\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5566; Mouse: 18747\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239015473331,"sku":"BT-AP11958-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239015506099,"sku":"BT-AP11958-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239015538867,"sku":"BT-AP11958-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5c7bdfb3-bcf3-417a-b4dd-143b6fb5cfd4.png?v=1769387955","url":"https:\/\/afsbio.com\/products\/pka-c-phospho-thr197-rabbit-polyclonal-antibody-bt-ap11958","provider":"AFSBio Inc.","version":"1.0","type":"link"}