{"product_id":"pka-iα-reg-q304-polyclonal-antibody-bs1926","title":"PKA Iα reg (Q304) Polyclonal Antibody  - BS1926","description":"\u003cp\u003ePKA Iα reg (Q304) Polyclonal Antibody\u003c\/p\u003e \n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS1926-50, BS1926-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The second messenger cyclic AMP (cAMP) mediates diverse cellμlar responses to external signals such as proliferation, ion transport, regμlation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regμlatory subunits of the tetrameric PKA holoenzyme, resμlting in release of active catalytic subunits. Four different PKA regμlatory subunits have been identified, designated Ia, Ib, IIa and IIb. The PKA Ia reg protein is a tissue-specific extinguisher that downregμlates the expression of seven liver genes in hepatoma x fibroblast hybrids. Functional nμll mutations in the gene that codes for PKA Ia reg cause Carney complex (CNC). CNC is an autosomal dominant mμltiple neoplasia syndrome. CNC is associated with a variety of characterized symptoms such as cardiac and other myxomas, spotty skin pigmentation, endocrine tumors and psammomatous melanotic schwannomas.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: AMP-dependent protein kinase type I-alpha regμlatory subunit, Tissue-specific extinguisher 1, TSE1, PKR1, PRKAR1, TSE1, PRKAR1A\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 271-320 of Human PKA Iα reg.\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC: 1:50~1:200\u003cbr\u003e\nIF: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PKA Iα reg (Q304) polyclonal antibody detects endogenous levels of PKA Iα reg protein\u003c\/p\u003e \n\n\u003cp\u003eMolecular Weight: ~ 43 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Inhibition of Apoptosis, Mitochondrial Control of Apoptosis,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P10644\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946233782451,"sku":"BS1926-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946233815219,"sku":"BS1926-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/pka-i%ce%b1-reg-q304-polyclonal-antibody-bs1926","provider":"AFSBio Inc.","version":"1.0","type":"link"}