{"product_id":"pkcalpha-beta-ii-phospho-thr638-641-rabbit-polyclonal-antibody-bt-ap11959","title":"PKCAlpha\/beta II (Phospho-Thr638\/641) Rabbit Polyclonal Antibody - BT-AP11959","description":"\u003cp\u003ePKCAlpha\/beta II (Phospho-Thr638\/641) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP11959-20, BT-AP11959-50, BT-AP11959-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters| a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes| such as cell adhesion| cell transformation| cell cycle checkpoint| and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Signal transduction; Cardiovascular; Cancer\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PKC alpha\/beta II\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P17252; Mouse: P20444; Rat: P05696\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PKCα\/β II;Thr638\/641; Protein kinase C alpha type; PKC-A; PKC-alpha; EC 2.7.11.13\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5578; Mouse: 18750\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238925852851,"sku":"BT-AP11959-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238925885619,"sku":"BT-AP11959-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238925918387,"sku":"BT-AP11959-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_7e67517a-4a43-4bee-a76b-81f84004d772.png?v=1769386779","url":"https:\/\/afsbio.com\/products\/pkcalpha-beta-ii-phospho-thr638-641-rabbit-polyclonal-antibody-bt-ap11959","provider":"AFSBio Inc.","version":"1.0","type":"link"}