{"product_id":"pkd1-phospho-ser205-rabbit-polyclonal-antibody-es6786","title":"PKD1 (phospho Ser205) Rabbit Polyclonal Antibody - ES6786","description":"\u003cp\u003ePKD1 (phospho Ser205) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6786-50, ES6786-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: PRKD1 is a serine\/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: PRKD1, PKD, PKD1, PRKCM, Serine\/threonine-protein kinase D1, Protein kinase C mu type, Protein kinase D, nPKC-D1, nPKC-mu\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human PKD1\/PKC mu around the phosphorylation site of Ser205. AA range:171-220\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: PKD1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Phospho-PKD1 (S205) Polyclonal Antibody detects endogenous levels of PKD1 protein only when phosphorylated at S205.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Placenta, Testis,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 110kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Rap1 signaling pathway, Aldosterone synthesis and secretion, Chemical carcinogenesis - reactive oxygen species\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein\u003cbr\u003e\nEnzyme Regulation: Activated by diacylglycerol and phorbol esters\u003cbr\u003e\nFunction: Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase involved in resistance to oxidative stress\u003cbr\u003e\nPTM: Phosphorylation of Ser-738 and\/or Ser-742 in activated PKD is mediated by transphosphorylation (By similarity). Phosphorylation of Tyr-463 mediated by the Src\/Abl pathway in response to oxidative stress activates the kinase\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily. CAMK Ser\/Thr protein kinase family. PKD subfamily\u003cbr\u003e\nSimilarity: Contains 1 PH domain\u003cbr\u003e\nSimilarity: Contains 1 protein kinase domain\u003cbr\u003e\nSimilarity: Contains 2 phorbol-ester\/DAG-type zinc fingers\u003cbr\u003e\nSubunit: Interacts (via N-terminus) with ADAP1\/CENTA1. Interacts with Src\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cytoplasm Cell membrane Golgi apparatus, trans-Golgi network Translocation to the cell membrane is required for kinase activation\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: PRKD1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Serine\/threonine-protein kinase D1\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 18760\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q62101\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 85421\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q9WTQ1\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313640591539,"sku":"ES6786-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313640624307,"sku":"ES6786-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/pkd1-phospho-ser205-rabbit-polyclonal-antibody-es6786","provider":"AFSBio Inc.","version":"1.0","type":"link"}