{"product_id":"pkd2-phospho-ser876-rabbit-pab-es1432","title":"PKD2 (phospho Ser876) rabbit pAb - ES1432","description":"\u003cp\u003ePKD2 (phospho Ser876) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1432-50, ES1432-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine\/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: PRKD2; PKD2; HSPC187; Serine\/threonine-protein kinase D2; nPKC-D2\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human PKD2 around the phosphorylation site of Ser876. AA range:829-878\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 96kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 25865\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q9BZL6\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm. Cell membrane. Nucleus. Golgi apparatus trans-Golgi network. Translocation to the cell membrane is required for kinase activation. Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202013847731,"sku":"ES1432-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202013880499,"sku":"ES1432-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_427ab3a3-86a1-45f9-b3ad-444a9d0ad7b5.png?v=1767119943","url":"https:\/\/afsbio.com\/products\/pkd2-phospho-ser876-rabbit-pab-es1432","provider":"AFSBio Inc.","version":"1.0","type":"link"}