{"product_id":"pkn1-monoclonal-antibody-bt-mca2014","title":"PKN1 Monoclonal Antibody - BT-MCA2014","description":"\u003cp\u003ePKN1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2014-50, BT-MCA2014-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1\/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PKN1\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, ICC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 4H10B1\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2b\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PKN1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human PKN1 (AA: 442-620) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 104kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q16512\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: DBK, PKN, PAK1, PRK1, PAK-1, PRKCL1, PKN-ALPHA\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5585\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238559113395,"sku":"BT-MCA2014-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238559146163,"sku":"BT-MCA2014-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_b5982b4e-247f-4741-ae29-63fa194266c9.png?v=1769382558","url":"https:\/\/afsbio.com\/products\/pkn1-monoclonal-antibody-bt-mca2014","provider":"AFSBio Inc.","version":"1.0","type":"link"}