{"product_id":"pla2g16-polyclonal-antibody-e-ab-53452","title":"PLA2G16 Polyclonal Antibody - E-AB-53452","description":"\u003cp\u003ePLA2G16 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-53452-60, E-AB-53452-120, E-AB-53452-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PLA2G16\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Adipose specific phospholipase A2; Adipose specific PLA2; Adipose-specific phospholipase A2; AdPLA; Ca independent phospholipase A1\/2; Group XVI phospholipase A1\/A2; Group XVI phospholipase A2; H rev 107 protein homolog; H REV107 1; H-rev 107 protein homolog; HRAS like suppressor 1; HRAS like suppressor 3; HRAS-like suppressor 1; HRAS-like suppressor 3; HREV107 1; HREV107 3; HREV107; HREV107-1; HREV107-3; HRSL3; HRSL3; Phospholipase A2 group XVI; Pla2g16; Renal carcinoma antigen NY REN 65 ; Renal carcinoma antigen NY-REN-65\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P53816\u003c\/p\u003e\n\n\u003cp\u003eBackground: Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and eicosanoids, and have a number of biological actions including immunological responses, inflammation, cellular proliferation, vasoconstriction, and bronchioconstriction. Exhibits PLA1\/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue (By similarity). N- and O-acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide of human PLA2G16\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:30-1:150, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43133584474291,"sku":"E-AB-53452-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43133584507059,"sku":"E-AB-53452-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43133584539827,"sku":"E-AB-53452-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_376c8e1f-588e-4c5e-92dd-42eb66866d2b.png?v=1709900473","url":"https:\/\/afsbio.com\/products\/pla2g16-polyclonal-antibody-e-ab-53452","provider":"AFSBio Inc.","version":"1.0","type":"link"}