{"product_id":"plasma-kallikrein-lc-cleaved-i391-rabbit-pab-es20042","title":"Plasma Kallikrein LC (Cleaved-I391) rabbit pAb - ES20042","description":"\u003cp\u003ePlasma Kallikrein LC (Cleaved-I391) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20042-50, ES20042-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin., disease:Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also called Fletcher factor deficiency. This disorder is a blood coagulation defect., function:The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin., similarity:Belongs to the peptidase S1 family., similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily., similarity:Contains 1 peptidase S1 domain., similarity:Contains 4 apple domains., subunit:The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: Plasma kallikrein (EC 3.4.21.34; Fletcher factor; Kininogenin; Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA; IHC\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human Plasma Kallikrein LC (Cleaved-I391)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 28 70kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 3818\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P03952\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Secreted\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202426626227,"sku":"ES20042-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202426658995,"sku":"ES20042-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_8f867560-6343-427a-9c00-29d3579f6a9d.png?v=1767128958","url":"https:\/\/afsbio.com\/products\/plasma-kallikrein-lc-cleaved-i391-rabbit-pab-es20042","provider":"AFSBio Inc.","version":"1.0","type":"link"}