{"product_id":"plc-gamma1-phospho-ser1248-rabbit-polyclonal-antibody-bt-ap04182","title":"PLC gamma1 (Phospho-Ser1248) Rabbit Polyclonal Antibody - BT-AP04182","description":"\u003cp\u003ePLC gamma1 (Phospho-Ser1248) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP04182-20, BT-AP04182-50, BT-AP04182-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene catalyzes the formation of inositol 1|4|5-trisphosphate and diacylglycerol from phosphatidylinositol 4|5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example| when activated by SRC| the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi| where it activates Ras. Also| this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Cardiovascular; Metabolism; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PLCG1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PLCγ1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P19174; Mouse: Q62077; Rat: P10686\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PLCγ1;Ser1248; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase gamma-1; EC 3.1.4.11; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5335; Mouse: 18803; Rat: 25738\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239016095923,"sku":"BT-AP04182-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239016128691,"sku":"BT-AP04182-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239016161459,"sku":"BT-AP04182-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_0476d997-9981-449c-a975-669284d44eb0.png?v=1769387967","url":"https:\/\/afsbio.com\/products\/plc-gamma1-phospho-ser1248-rabbit-polyclonal-antibody-bt-ap04182","provider":"AFSBio Inc.","version":"1.0","type":"link"}