{"product_id":"plscr1-polyclonal-antibody-bs8540","title":"PLSCR1 Polyclonal Antibody-BS8540","description":"\u003cp\u003ePLSCR1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS8540-50, BS8540-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O15162\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Phospholipid scramblase 1 (PLSCR1) is 1 of 4 scramblases encoded in the human genome. Phospholipid scramblases function to catalyze calcium-mediated ATP-independent mobilization of phospholipids between the inner and outer leaflet of plasma membrane in activated, injured, or apoptotic cells. PLSCR1 is a type-II transmembrane protein with a short 9 amino acid C-terminal domain and a long N-terminal extracellular domain. Although PLSCR1 is part of a family of proteins that function to catalyze phospholipid mobilization, PLSCR1 may have alternative functions. Rather, PLSCR1 may function to activate cell signaling pathways, particularly in phagocytic cells of monocyte\/macrophage lineage. Microglia, resident macrophages of the brain, play a key role in clearance of cellular and pathologic debris where altered phagocytosis may contribute to neurodegenerative diseases like Alzheimer’s disease. PLSCR1 may regulate microglia phagocytosis, representing a potential therapeutic target to modulate microglia phagocytosis.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PLSCR1 polyclonal antibody detects endogenous levels of PLSCR1 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of PLSCR1 polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLaneA:H9C2 whole cell lysate(40ug)\u003cbr\u003e\nLaneB:CT26 whole cell lysate(40ug)\u003cbr\u003e\nLaneC:HepG2 whole cell lysate(40ug)\u003cbr\u003e\nLaneD:HCT116 whole cell lysate(40ug)\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 36 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Phospholipid scramblase 1; PL scramblase 1; Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; Mg(2+)-dependent nuclease ; PLSCR1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human PLSCR1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42908707487923,"sku":"BS8540-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42908707520691,"sku":"BS8540-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_a3b15e70-a01a-4e52-b73e-17d3706919b3.jpg?v=1703006078","url":"https:\/\/afsbio.com\/products\/plscr1-polyclonal-antibody-bs8540","provider":"AFSBio Inc.","version":"1.0","type":"link"}