{"product_id":"pms2-monoclonal-antibody-bt-mca4574","title":"PMS2 Monoclonal Antibody - BT-MCA4574","description":"\u003cp\u003ePMS2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4574-50, BT-MCA4574-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion\/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PMS2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FCM\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 5A7F2\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2b\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PMS2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human PMS2 (AA: 748-851) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 95.8kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P54278\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: MLH4, PMSL2, HNPCC4, PMS2CL\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5395\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238413394099,"sku":"BT-MCA4574-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238413426867,"sku":"BT-MCA4574-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d1750b57-b23b-437b-96da-3413a1d43439.png?v=1769380319","url":"https:\/\/afsbio.com\/products\/pms2-monoclonal-antibody-bt-mca4574","provider":"AFSBio Inc.","version":"1.0","type":"link"}