{"product_id":"pms2-polyclonal-antibody-bz16553","title":"PMS2 Polyclonal Antibody-BZ16553","description":"\u003cp\u003ePMS2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BZ16553-50, BZ16553-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P54278\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003ePMS2 Polyclonal Antibody-BZ16553\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-P, ICC\/IF, IP, , FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1\/500-1\/1000 IHC: 1\/50-1\/100 IF: 1\/50-1\/200 IP: 1\/20 FC: 1\/50-1\/100\u003c\/p\u003e\n\n\u003cp\u003eBackground: Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: Calculated MW: 96 kDa; Observed MW: 110 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of PMS2 in JurkatLysates; HeLaLysates using PMS2 antibody., Immunohistochemistry analysis of paraffin-embedded Human tonsil using PMS2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: DNA mismatch repair gene; DNA mismatch repair protein PMS2; HNPCC4; PMS1 protein homolog 2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthesized peptide derived from human PMS2\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42957316980915,"sku":"BZ16553-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42957317013683,"sku":"BZ16553-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_f386bccb-4df6-4c01-8b36-ffefe89f943b.jpg?v=1705144781","url":"https:\/\/afsbio.com\/products\/pms2-polyclonal-antibody-bz16553","provider":"AFSBio Inc.","version":"1.0","type":"link"}