{"product_id":"pon1-rabbit-pab-a1321","title":"PON1 Rabbit pAb - A1321","description":"\u003cp\u003ePON1 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A1321-20, A1321-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 40kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 52kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment)\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5444\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P27169\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ESA; PON; MVCD5; PON1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:2000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction, Cell Biology Developmental Biology, Endocrine Metabolism, Lipid Metabolism, Drug metabolism, Endocrine and metabolic diseases, Diabetes, Neuroscience, Neurodegenerative Diseases, Dopamine Signaling in Parkinson's Disease, Cardiovascular, Lipids.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: PON1\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189551259827,"sku":"A1321-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189551292595,"sku":"A1321-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_7c86cb77-f038-401f-8e2a-f5c9ae7f835a.png?v=1766429638","url":"https:\/\/afsbio.com\/products\/pon1-rabbit-pab-a1321","provider":"AFSBio Inc.","version":"1.0","type":"link"}