{"product_id":"poteg-polyclonal-antibody-bs62434","title":"POTEG Polyclonal Antibody-BS62434","description":"\u003cp\u003ePOTEG Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS62434-50, BS62434-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q6S5H5; Q6S545; A6NI47\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB  IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500~1:1000  IHC:1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: POTE ankyrin domain family, member G ( poteg ) belongs to POTE family. The POTE family is composed of many proteins which are very closely related and expressed in prostate, ovary, testis, and placenta. Some POTE paralogs are related with some cancers. Here we showed that down‐regulation of POTEG was detected in about 60% primary esophageal squamous cell carcinoma (ESCC) tumor tissues. Clinical association studies determined that POTEG down‐regulation was significantly correlated with tumor differentiation, lymph nodes metastasis and TNM staging. Kaplan‐Meier analysis determined that POTEG down‐regulation was associated with poorer clinical outcomes of ESCC patients ( P = 0.026). Functional studies showed that POTEG overexpression could suppress tumor cell growth and metastasis capacity in vitro and in vivo. Molecular analyses revealed that POTEG downregulated CDKs, leading to subsequent inhibition of Rb phosphorylation, and consequently arrested Cell Cycle at G1\/S Checkpoint.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The protein was purified from E.coli and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: POTEG polyclonal antibody detects endogenous levels of POTEG protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of POTEG polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLaneA:A549 whole cell lysate\u003cbr\u003e\nLaneB:The testis tissue lysate of Mouse\u003cbr\u003e\nLaneC:The testis tissue lysate of Rat\u003cbr\u003e\nLaneD:The brain tissue lysate of Mouse\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 58,54 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: POTE ankyrin domain family member G; ANKRD26-like family C member 2; Prostate, ovary, testis-expressed protein on chromosome 14; POTE-14; POTEG; A26C2; POTE14\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human POTEG.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42910458020019,"sku":"BS62434-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42910458052787,"sku":"BS62434-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_96bc4894-e355-4338-953f-0a2d92cacccc.jpg?v=1703092798","url":"https:\/\/afsbio.com\/products\/poteg-polyclonal-antibody-bs62434","provider":"AFSBio Inc.","version":"1.0","type":"link"}