{"product_id":"pp2aα-β-polyclonal-antibody-bs91098","title":"PP2Aα\/β Polyclonal Antibody-BS91098","description":"\u003cp\u003ePP2Aα\/β Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91098-50, BS91098-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P62714(Human) P67775(Human) P62715(Mouse) P63330(Mouse) P62716(Rat) P63331(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, zebrafish\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC, IHC, IP,\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB:1:1,000-1:2,000\u003cbr\u003e\nICC:1:50-1:200\u003cbr\u003e\nIHC:1:100-1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: The catalytic subunit of protein phosphatase 2A (PP2A) is inactivated by in vitro phosphorylation of Tyr-307 by receptor and nonreceptor protein tyrosine kinases. The catalytic subunit of PP2A is phosphorylated by tyrosine-specific protein kinases and associates with a variety of regulatory subunits. Phosphorylation is enhanced in the presence of the phosphatase inhibitor okadaic acid, consistent with an autodephosphorylation reaction. Phosphorylation is catalyzed by p60v-src, p56lck, epidermal growth factor receptors, and insulin receptors. Transient deactivation of PP2A might enhance transmission of cellular signals through kinase cascades within cells. In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PP2Aα\/β polyclonal antibody detects endogenous levels of PP2Aα\/β protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 36 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of PP2A alpha + beta on different lysates using anti-PP2A alpha + beta antibody at 1\/1,000 dilution. \u003cbr\u003e\n Positive control:\u003cbr\u003e\n Lane 1: A431\u003cbr\u003e\n Lane 2: NIH\/3T3\u003cbr\u003e\n Lane 3: 293T, ICC staining PP2A alpha + beta in PANC-1 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: PP2A-alpha, RP-C, PPP2CA, PP2A-beta, PPP2CB, PP2A A, PP2A alpha, PP2A B, PP2A beta, PP2A-alpha, PP2AA, PP2Ac, PP2CB, PPP2CA, PPP2CB, Protein phosphatase 2 catalytic subunit alpha isoform, Protein phosphatase 2 catalytic subunit beta isoform, Replication protein C, RP C, RP-C, Serine\/threonine protein phosphatase 2A catalytic subunit alpha isoform, Serine\/threonine protein phosphatase 2A catalytic subunit beta isoform, Serine\/threonine-protein phosphatase 2A catalytic subunit alpha isoform,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42984614887603,"sku":"BS91098-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42984614920371,"sku":"BS91098-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_ac9d66a6-cac2-460a-91ba-d23f6073b62f.jpg?v=1705919382","url":"https:\/\/afsbio.com\/products\/pp2a%ce%b1-%ce%b2-polyclonal-antibody-bs91098","provider":"AFSBio Inc.","version":"1.0","type":"link"}