{"product_id":"pp2b-aα-rabbit-pab-es20264","title":"PP2B-Aα rabbit pAb - ES20264","description":"\u003cp\u003ePP2B-Aα rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20264-50, ES20264-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:A phosphoprotein + H (2)O = a protein + phosphate., cofactor:Binds 1 Fe (3+) ion per subunit., cofactor:Binds 1 zinc ion per subunit., function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1., online information:Calcineurin entry, similarity:Belongs to the PPP phosphatase family., similarity:Belongs to the PPP phosphatase family. PP-2B subfamily., subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle., subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2\/CRTC2, MYOZ1, MYOZ2 and MYOZ3.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: Serine\/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform)\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human PP2B-Aα\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 5530\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q08209\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm. Cell membrane; Peripheral membrane protein. Cell membrane, sarcolemma. Cytoplasm, myofibril, sarcomere, Z line. Cell projection, dendritic spine. Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca (2+)-channel activation (PubMed:22343722).\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201959551155,"sku":"ES20264-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201959583923,"sku":"ES20264-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_b4617539-e759-4b14-adac-795e2c927abf.png?v=1767118910","url":"https:\/\/afsbio.com\/products\/pp2b-a%ce%b1-rabbit-pab-es20264","provider":"AFSBio Inc.","version":"1.0","type":"link"}