{"product_id":"pp2b-a-alpha-monoclonal-antibody-bt-mca1049","title":"PP2B-A Alpha Monoclonal Antibody - BT-MCA1049","description":"\u003cp\u003ePP2B-A Alpha Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA1049-50, BT-MCA1049-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 Fe(3+) ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.,online information:Calcineurin entry,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-2B subfamily.,subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.,subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2\/CRTC2, MYOZ1, MYOZ2 and MYOZ3.,\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction; Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PPP3CA\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human,Mouse,Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Serine,threonine-protein phosphatase 2B catalytic subunit alpha isoform\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q08209; Mouse: P63328; Rat: P63329\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PPP3CA; CALNA; CNA; Serine; threonine-protein phosphatase 2B catalytic subunit alpha isoform; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5530; Mouse: 19055; Rat: 24674\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238746579123,"sku":"BT-MCA1049-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238746611891,"sku":"BT-MCA1049-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_604e275d-5f2b-40b3-a863-162d61555720.png?v=1769384330","url":"https:\/\/afsbio.com\/products\/pp2b-a-alpha-monoclonal-antibody-bt-mca1049","provider":"AFSBio Inc.","version":"1.0","type":"link"}