{"product_id":"pp2cε-rabbit-polyclonal-antibody-es4910","title":"PP2Cε Rabbit Polyclonal Antibody - ES4910","description":"\u003cp\u003ePP2Cε Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4910-50, ES4910-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: PPM1L, PP2CE, Protein phosphatase 1L, Protein phosphatase 1-like, Protein phosphatase 2C isoform epsilon, PP2C-epsilon\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human PPM1L. AA range:119-168\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: PP2Cε\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PP2Cε Polyclonal Antibody detects endogenous levels of PP2Cε protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Ubiquitous, Highly expressed in heart, placenta, lung, liver, kidney and pancreas,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 48kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: A phosphoprotein + H(2)O = a protein + phosphate\u003cbr\u003e\nCofactor: Binds 2 magnesium or manganese ions per subunit\u003cbr\u003e\nFunction: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7\/TAK1 and MAP3K5, and by attenuating the association between MAP3K7\/TAK1 and MAP2K4 or MAP2K6\u003cbr\u003e\nSimilarity: Belongs to the PP2C family\u003cbr\u003e\nSimilarity: Contains 1 PP2C-like domain\u003cbr\u003e\nSubunit: Interacts with MAP3K7\/TAK1 (By similarity). Interacts with MAP3K5\u003cbr\u003e\nTissue Specificity: Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Membrane, Single-pass type I membrane protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: PPM1L\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Protein phosphatase 1L\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 242083\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8BHN0\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313511813299,"sku":"ES4910-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313511846067,"sku":"ES4910-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/pp2c%ce%b5-rabbit-polyclonal-antibody-es4910","provider":"AFSBio Inc.","version":"1.0","type":"link"}