{"product_id":"ppm1a-monoclonal-antibody-bt-mca2944","title":"PPM1A Monoclonal Antibody - BT-MCA2944","description":"\u003cp\u003ePPM1A Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2944-50, BT-MCA2944-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the PP2C family of Ser\/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53\/p53, which leads to G2\/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling, Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PPM1A\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Monkey\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 7F12H6\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PPM1A\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 42.4kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P20265\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PP2CA, PP2Calpha, PP2C-ALPHA\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5494\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238577987763,"sku":"BT-MCA2944-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238578020531,"sku":"BT-MCA2944-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_6dc8f573-6b19-432c-b501-e326f7b1e0dd.png?v=1769382751","url":"https:\/\/afsbio.com\/products\/ppm1a-monoclonal-antibody-bt-mca2944","provider":"AFSBio Inc.","version":"1.0","type":"link"}