{"product_id":"ppm1m-polyclonal-antibody-e-ab-19190","title":"PPM1M Polyclonal Antibody - E-AB-19190","description":"\u003cp\u003ePPM1M Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-19190-60, E-AB-19190-120, E-AB-19190-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PPM1M\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: FLJ32332; PP2C eta; PP2C-eta; PP2CE; PP2Ceta; PPM1M; PPM1M; protein phosphatase 1M (PP2C domain containing); Protein phosphatase 1M; Protein phosphatase 2C isoform eta\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q96MI6\u003c\/p\u003e\n\n\u003cp\u003eBackground: PPM1M is a member of the PP2C family of Ser\/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase was identified as an interacting protein of Rho guanine nucleotide exchange factors (PIX). PIX proteins are regulators of p21\/Cdc42\/Rac1-activated kinase 1 (PAK1), a protein kinase mediating biological effects downstream of Rho GTPases. This phosphatase has been shown to block the effects of PAK, and thus inhibit actin stress fiber breakdown and morphological changes driven by cell division cycle 42 (CDC42).\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.74 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fusion protein of human PPM1M\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:100-1:300, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43130753482931,"sku":"E-AB-19190-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43130753515699,"sku":"E-AB-19190-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43130753548467,"sku":"E-AB-19190-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_5d716a32-63c4-4795-90f8-4a65d0aac410.png?v=1709812226","url":"https:\/\/afsbio.com\/products\/ppm1m-polyclonal-antibody-e-ab-19190","provider":"AFSBio Inc.","version":"1.0","type":"link"}