{"product_id":"pr-phospho-ser400-rabbit-pab-es6580","title":"PR (phospho Ser400) rabbit pAb - ES6580","description":"\u003cp\u003ePR (phospho Ser400) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6580-50, ES6580-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: PGR; NR3C3; Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human Progesterone Receptor around the phosphorylation site of Ser400. AA range:371-420\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 99kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 5241\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P06401\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Cytoplasm. Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G (1) and G (2)\/M phases.; [Isoform A]: Nucleus. Cytoplasm. Mainly nuclear.; [Isoform 4]: Mitochondrion outer membrane.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202304598195,"sku":"ES6580-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202304630963,"sku":"ES6580-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_024e246f-5066-4919-86c5-13d8a4ba1c81.png?v=1767126164","url":"https:\/\/afsbio.com\/products\/pr-phospho-ser400-rabbit-pab-es6580","provider":"AFSBio Inc.","version":"1.0","type":"link"}