{"product_id":"presenilin-1-polyclonal-antibody-bt-ap07396","title":"Presenilin 1 Polyclonal Antibody - BT-AP07396","description":"\u003cp\u003ePresenilin 1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP07396-20, BT-AP07396-50, BT-AP07396-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PSEN1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Presenilin 1 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 52668\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P49768; Mouse: P49769; Rat: P97887\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5663; Mouse: 19164; Rat: 29192\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239852499123,"sku":"BT-AP07396-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239852531891,"sku":"BT-AP07396-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239852564659,"sku":"BT-AP07396-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_62a5751f-a674-4ef6-8057-a54442f17125.png?v=1769399991","url":"https:\/\/afsbio.com\/products\/presenilin-1-polyclonal-antibody-bt-ap07396","provider":"AFSBio Inc.","version":"1.0","type":"link"}